Alzheimer - parent compound amyloid precursor protein

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Alzheimer - parent compound amyloid precursor protein

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1. alzheimer parent compound amyloid precursor protein

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• The present invention relates to the treatment of Alzheimer`s disease and other similar diseases, and more specifically to the use of compounds that inhibit beta-secretase, an enzyme that cleaves amyloid precursor protein to produce A beta

The present invention provides compounds, compositions, kits, and methods for inhibiting beta-secretase-mediated cleavage of amyloid precursor protein (APP)

We have studied synaptic function in a transgenic mouse strain relevant to Alzheimer`s disease (AD), overexpressing the 695 amino acid isoform of human amyloid precursor protein with K670N and M671L mutations (APP(695)SWE mice), which is associated with early-onset familial AD

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