Alzheimer - currently known mutations affect beta-amyloid processing

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Alzheimer - currently known mutations affect beta-amyloid processing

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1. alzheimer currently known mutations affect beta-amyloid processing

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• Similar to the effects of FAD mutants on ICD generation of N-cadherin, some FAD mutations affect the generation of the APP and the Notch intracellular domain ()


• Recent and previous studies together suggest that the four known genetic mutations associated with familial Alzheimer`s disease increase the production or deposition of the amyloid beta protein in the brain


• The contribution of alpha-synuclein accumulation in Alzheimer`s disease (AD) plaques is currently a matter of scientific debate

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