Alzheimer - mediators beta-amyloid toxicity

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Alzheimer - mediators beta-amyloid toxicity

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1. alzheimer mediators beta-amyloid toxicity

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• Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer disease mouse models


• were originally considered the mediators of neurotoxicity in Alzheimer disease, recent research has underscored the roles


• , Genetic removal of tau from these transgenic mice led to reduced Alzheimer diseasetype pathologic features, suggesting that tau is essential for -amyloidinduced neuronal toxicity (at least in transgenic mice)

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